Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene

Zhang-Hui Chen,Yan P Yu,Ze-Hua Zuo,Joel B Nelson,George K Michalopoulos,Satdatshan Monga,Silvia Liu,George Tseng,Jian-Hua Luo

NATURE BIOTECHNOLOGY（2017）

引用 91|浏览47

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摘要

Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression of mouse xenograft tumors.

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关键词

Drug development,Gene targeting,Gene therapy,Targeted therapies,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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