MiR-34a contributes to diabetes-related cochlear hair cell apoptosis via SIRT1/HIF-1α signaling.

Ying Lin,Jinjin Shen,Danfeng Li,Jie Ming,Xiangyang Liu,Nana Zhang,Jingbo Lai,Min Shi,Qiuhe Ji,Ying Xing

General and Comparative Endocrinology（2017）

引用 34|浏览7

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摘要

•Diabetic db/db mice developed a hearing threshold shifts and significant hair cell loss.•MiR-34a plays an important role in diabetes-related hair cell loss by modulating SIRT1 and HIF-1α expression.•MiRNA-34a and HIF-1α are involved in the viability and apoptosis of HEI-OC1 cells induced by high glucose.•MiR-34a contributes to high-glucose-induced hair cell apoptosis via SIRT1/HIF-1α signaling pathway.

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关键词

miR-34a,T2DM,Hearing impairment (HI),SIRT1,HIF-1α

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