Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets Louise V Wain , Nick Shrine , María Soler Artigas , A Mesut Erzurumluoglu , Boris Noyvert , Lara Bossini-Castillo , Ma'en Obeidat , Amanda P Henry , Michael A Portelli , Robert J Hall , Charlotte K Billington , Tracy L Rimington , Anthony G Fenech , Catherine John , Tineka Blake , Victoria E Jackson , Richard J Allen , Bram P Prins , Archie Campbell , David J Porteous , Marjo-Riitta Jarvelin , Matthias Wielscher , Alan L James , Jennie Hui , Nicholas J Wareham , Jing Hua Zhao , James F Wilson , Peter K Joshi , Beate Stubbe , Rajesh Rawal , Holger Schulz , Medea Imboden , Nicole M Probst-Hensch , Stefan Karrasch , Christian Gieger , Ian J Deary , Sarah E Harris , Jonathan Marten , Igor Rudan , Stefan Enroth , Ulf Gyllensten , Shona M Kerr , Ozren Polasek , Mika Kähönen , Ida Surakka , Veronique Vitart , Caroline Hayward , Terho Lehtimäki , Olli T Raitakari , David M Evans , A John Henderson , Craig E Pennell , Carol A Wang , Peter D Sly , Emily S Wan , Robert Busch , Brian D Hobbs , Augusto A Litonjua , David W Sparrow , Amund Gulsvik , Per S Bakke , James D Crapo , Terri H Beaty , Nadia N Hansel , Rasika A Mathias , Ingo Ruczinski , Kathleen C Barnes , Yohan Bossé , Philippe Joubert , Maarten van den Berge , Corry-Anke Brandsma , Peter D Paré , Don D Sin , David C Nickle , Ke Hao , Omri Gottesman , Frederick E Dewey , Shannon E Bruse , David J Carey , H Lester Kirchner , Stefan Jonsson , Gudmar Thorleifsson , Ingileif Jonsdottir , Thorarinn Gislason , Kari Stefansson , Claudia Schurmann , Girish Nadkarni , Erwin P Bottinger , Ruth J F Loos , Robin G Walters , Zhengming Chen , Iona Y Millwood , Julien Vaucher , Om P Kurmi , Liming Li , Anna L Hansell , Chris Brightling , Eleftheria Zeggini , Michael H Cho , Edwin K Silverman , Ian Sayers , Gosia Trynka , Andrew P Morris , David P Strachan , Ian P Hall , Martin D Tobin Nature Genetics（2017）
摘要
Louise Wain, Ian Hall, Martin Tobin and colleagues report genome-wide association analyses of lung function, identifying 43 new signals associated with one or more lung function traits. A genetic risk score derived from these results was significantly associated with risk for chronic obstructive pulmonary disease in independent populations.
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关键词
Genetics research, Respiratory tract diseases, Genome-wide association studies
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