A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy.
CHEMICAL COMMUNICATIONS(2018)
摘要
Limited tumor tissue penetration is one of the key impeding factors retarding successful in vivo exploitations of anti-angiogenic cancer therapy. Herein we report on the design of a cell penetrating peptide-decorated lipid nano-assembly which, upon systemic administration, induces significant mouse tumor growth inhibition via enhanced tumor infiltration of encapsulated anti-angiogenic siRNA.
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关键词
Lipid Nanoparticles,Cell-penetrating Peptides,Therapeutic RNAi,siRNA Therapeutics
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