Glycogen phosphorylase: a novel biomarker in doxorubicin-induced cardiac injury.

Extracellular vesicles containing glycogen phosphorylase, brain/ heart (PYGB) have been demonstrated as a sensitive biomarker for normal cardiac injuries for patients after chemotherapy. Oxidative stress was suggested to be the mechanism behind the chemotherapy-induced tissue damage and augmented with mitochondrial antioxidant could be an effective means of early intervention. (C) 2018 AACR.