Direct anti-inflammatory effects of granulocyte colony-stimulating factor (G-CSF) on activation and functional properties of human T cell subpopulations in vitro

Vladimir Vladimirovich Malashchenko,Maxsim Evgenievich Meniailo,Viacheslav Anatolievich Shmarov,Natalia Dinislamovna Gazatova,Olga Borisovna Melashchenko,Andrei Gennadievich Goncharov,Galina Victorovna Seledtsova,Victor Ivanovich Seledtsov

Cellular Immunology（2018）

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摘要

•T-cell activation stimulates the G-CSFR (CD114) expression on T-cells.•Upon T-cell activation, G-CSF enhances the proportion of CD38+ T cells.•G-CSF down-regulates INF-γ production and of up-regulates IL-4 production.•G-CSF is able to constrain T-cell-driven, pro-inflammatory responses.

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关键词

Ab,G-CSF,G-CSFR,IFN,IL,PBMC,Th,Treg

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