Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages.

Xiao-Xiao Liu,Xiao-Wen Zhang,Kai Wang,Xue-Ying Wang, Wen-Long Ma,Wei Cao,Dan Mo,Yang Sun,Xiao-Qiang Li

Toxicology and Applied Pharmacology（2018）

引用 31|浏览11

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摘要

•KWG prevents macrophage foam cell formation by up-regulating LXRα-ABCA1/ABCG1.•KWG attenuates inflammatory response by diminishing NFκB activity.•KWG attenuates atherosclerosis development in ApoE−/− mice fed with HFD.

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关键词

Kuwanon G,Atherosclerosis,Macrophages,Foam cell formation,Inflammatory

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