Structural characterization and macrophage activation of a hetero-galactan isolated from Flammulina velutipes.

Yue Meng,Jingmin Yan,Guang Yang,Zhen Han,Guihua Tai,Hairong Cheng,Yifa Zhou

Carbohydrate Polymers（2018）

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摘要

•A novel hetero-galactan (WFVP-N-b1) from F. velutipes was purified and identified.•WFVP-N-b1 increased phagocytosis and secretion of NO, ROS, TNF-α, IL-6 and IL-1β.•WFVP-N-b1 activated macrophages through MAPKs, autophagy and Akt/NF-κB via TLR4.•Macrophage activation by WFVP-N-b1 also occurred ex vivo and in vivo.

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关键词

TNF-α,IL-6,IL-1β,MAPKs,ERKs,JNK,DCFH-DA,PI,ROS,Baf-A1,GFP,MTT,NO

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