Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.

We identified two DNAm sites-cg07786668 in and cg17218495 in - that are independently and significantly associated with MI. Our results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by CVD-associated SNPs in these genes. The Kita-Nagoya Genomic Epidemiology (KING) study, which was the source of control samples in the present study, was registered in ClinicalTrials.gov (NCT00262691) on 6 December 2005.