Exploring the neuroprotective effects of ginkgolides injection in a rodent model of cerebral ischemia-reperfusion injury by GC-MS based metabolomic profiling.

Jian-Liang Geng, Ji-Ye Aa,Si-Qi Feng,Shu-Yao Wang,Pei Wang,Yue Zhang,Bing-Chen Ouyang,Jian-Kun Wang,Ye-Jin Zhu,Wen-Zhe Huang,Zhen-Zhong Wang,Wei Xiao,Guang-Ji Wang

Journal of Pharmaceutical and Biomedical Analysis（2017）

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摘要

•GC–MS based metabolomics coupled with MVDA was applied to profile metabolic perturbations in tMCAO rats.•Dynamic metabolites changes of tMCAO rats in the different stages of cerebral I/R injury were described.•GIn against cerebral I/R injury by modulating perturbed metabolic pathways.•Cerebal exposure to ginkgolides in tMCAO rats were strikingly increased after I/R.

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关键词

Metabolomic profiling,Cerebral ischemia–reperfusion injury,Ginkgolides injection,Neuroprotection,Cerebral exposure level

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