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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Brian Metcalf,Chihyuan Chuang,Kobina Dufu,Mira P. Patel,Abel Silva-Garcia, Carl Johnson, Qing Lu,James R. Partridge,Larysa Patskovska,Yury Patskovsky,Steven C. Almo,Matthew P. Jacobson,Lan Hua,Qing Xu,Stephen L. Gwaltney,Calvin Yee,Jason Harris,Bradley P. Morgan, Joyce James,Donghong Xu,Athiwat Hutchaleelaha, Kumar Paulvannan,Donna Oksenberg,Zhe Li

ACS Medicinal Chemistry Letters（2017）

引用 139|浏览43
关键词
Sickle cell disease,sickle cell hemoglobin,allosteric modulator,aldehyde,Schiff-base formation,oxygen affinity,red blood cell partitioning
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