Dose-Dependent Cardioprotection of Moderate (32°C) Versus Mild (35°C) Therapeutic Hypothermia in Porcine Acute Myocardial Infarction.

Rajesh Dash,Yoshiaki Mitsutake,Wook Bum Pyun,Fady Dawoud,Jennifer Lyons,Atsushi Tachibana,Kazuyuki Yahagi,Yuka Matsuura,Frank D Kolodgie,Renu Virmani,Michael V McConnell,Uday Illindala,Fumiaki Ikeno,Alan Yeung

JACC: Cardiovascular Interventions（2018）

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摘要

Moderate (32°C) therapeutic hypothermia demonstrated superior and near-complete cardioprotection compared with 35°C and control, warranting further investigation into clinical applications.

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关键词

acute MI,cardiac MRI dose response,hypothermia,ischemia-reperfusion injury

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