Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients.

Philip E Silkoff,Michel Laviolette,Dave Singh,J Mark FitzGerald,Steven Kelsen,Vibeke Backer,Celeste M Porsbjerg,Pierre-Olivier Girodet,Patrick Berger,Joel N Kline,Geoffrey Chupp,Vedrana S Susulic,Elliot S Barnathan,Frédéric Baribaud,Matthew J Loza

Journal of Allergy and Clinical Immunology（2017）

引用 57|浏览18

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摘要

A panel of clinical biomarkers accurately classified type 2 status based on airway mucosal CCL26, periostin, or IL-13-IVS gene expression. Use of Feno values, bEOS counts, and serum marker levels (eg, CCL26 and CCL17) in combination might allow patient selection for novel type 2 therapeutics.

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关键词

Asthma,type 2 inflammation,phenotypes,airway mucosal gene expression,biomarkers

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