Morphine responsiveness to thermal pain stimuli is aging-associated and mediated by dopamine D1 and D3 receptor interactions.

Sophia Samir, Alexander P Yllanes,Perrine Lallemand,Kori L Brewer,Stefan Clemens

Neuroscience（2017）

引用 12|浏览4

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摘要

•Pain withdrawal reflexes are age-dependent and dopamine D3 receptor-mediated.•Block of dopamine D1 receptor in young D3KO animals mimics aged wild-type controls.•In old animals, dopamine D1 receptor block can mimic analgesic effects of morphine.

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关键词

D3KO,DA,MOR,WT

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