Activation of GPER ameliorates experimental pulmonary hypertension in male rats.

Allan K Alencar,Guilherme C Montes,Tadeu Montagnoli,Ananssa M Silva,Sabrina T Martinez,Aline G Fraga,Hao Wang,Leanne Groban,Roberto T Sudo,Gisele Zapata-Sudo

European Journal of Pharmaceutical Sciences（2017）

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摘要

GPER activation by G1 reverses pulmonary hypertension in male rats by promoting pulmonary endothelial nitric oxide synthesis, Ca2+ handling regulation and reduction of inflammation in cardiomyocytes, and a decrease of collagen deposition by acting in pulmonary and cardiac fibroblasts.Image 1

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关键词

GPER,Monocrotaline,Vascular remodeling,Right ventricular dysfunction

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