ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.

Reba Mustafi,Urszula Dougherty,Devkumar Mustafi,Fatma Ayaloglu-Butun,Michelle Fletcher,Sarbani Adhikari,Farhana Sadiq,Katherine Meckel,Haider I Haider,Abdurahman Khalil,Joel Pekow,Vani Konda,Loren Joseph,John Hart,Alessandro Fichera,Yan Chun Li,Marc Bissonnette

Clinical cancer research : an official journal of the American Association for Cancer Research（2017）

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摘要

ADAM17 is a Western diet-inducible enzyme activated by CXCL12-CXCR4 signaling, suggesting the pathway: Western diet→CXCL12→CXCR4→ADAM17→TGFα→EGFR. ADAM17 might serve as a druggable target in chemoprevention strategies. Clin Cancer Res; 23(2); 549-61. ©2016 AACR.

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