The Relationship Between Cholesterol Level And Alzheimer'S Disease-Associated App Proteolysis/A Beta Metabolism

Globally, Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the elderly population, the hallmark of which is amyloid beta (A beta) peptide. Energy metabolism and AD pathogenesis are believed to influence one another. Different cholesterol levels are thought to influence various steps in neurotoxic A beta generation, including amyloid precursor protein (APP) proteolysis and the corresponding activities of alpha-, beta-, and gamma-secretases. In addition, cholesterol has been proved to mediate A beta metabolism, such as its fibrillation, transportation, degradation, and clearance processes. The current review discusses in detail the intimate interaction between the cholesterol level and the various aspects of APP proteolysis and A beta metabolism.