The Expression of Inflammatory Mediators in Bladder Pain Syndrome.

Ifeoma Offiah,Athanasios Didangelos,John Dawes,Rufus Cartwright,Vik Khullar,Elizabeth J Bradbury,Suzanne O'Sullivan, Dic Williams,Iain P Chessell, Kenny Pallas,Gerry Graham,Barry A O'Reilly,Stephen B McMahon

European Urology（2016）

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摘要

Bladder pain syndrome (BPS) pathology remains poorly understood, and its treatment is difficult. We identified mediators that, from our study of their action in the bladders of laboratory animals, may be implicated in disease pathology. These mediators are unexploited therapeutic targets for BPS treatment.

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关键词

Animal model,Bladder pain syndrome,CCL21,Clinical correlation,FGF7,Gene expression analysis,Interstitial cystitis,Pain behaviour

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