The 3-methyl-4-nitrophenol (PNMC) compromises airway epithelial barrier function.
Toxicology(2018)
摘要
•Exposure of mice to 4-nitro-m-cresol (PNMC) induced nasal epithelial cell apoptosis.•Exposure of mice to PNMC increased the permeability of the nasal epithelial barrier.•PNMC increased casp8 and casp3 activities in nasal epithelial cells.•Exposure to PNMC up regulated Fas and FasL expression in airway epithelial cells.•Inhibition of caspase abolished the PNMC-induced airway epithelial barrier dysfunction.
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关键词
Epithelial barrier functions,Apoptosis,Air pollution,Automobile-exhaust particles,Caspases
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