A pathogenetic role for M1 macrophages in peritoneal dialysis-associated fibrosis.

Qing Li,Min Zheng,Yueheng Liu,Wei Sun,Jun Shi,Jie Ni,Qiong Wang

Molecular Immunology（2018）

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摘要

•Systemic depletion of monocytes/macrophages abrogated PDFs-induced peritoneal damage and dysfunction.•M1 macrophages reperfusion aggravates PDFs-induced peritoneal damage and dysfunction.•M1 macrophages are an important mediator of peritoneal fibrosis. TLR4 expression was enhanced in M1 macrophage-treated group.

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关键词

PD,PDFs,PF,LC,LV,ECM,EMT,TLR4,α-SMA

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