Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae

Yoshihiro Watanabe,Yukihiro Asami,Satomi Narusawa,Shohei Hashimoto,Masato Iwatsuki,Kenichi Nonaka,Yasuo Shinohara,Takahiro Shiotsuki,Naoya Ichimaru,Hideto Miyoshi,Satoshi Ōmura,Kazuro Shiomi

JOURNAL OF ANTIBIOTICS（2017）

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摘要

A new lanostane-type triterpenoid, ascosteroside D, was isolated from a fungus, Aspergillus sp. FKI-6682. It inhibited insect ADP/ATP carrier protein (AAC)-expressing Saccharomyces cerevisiae in glycerol-containing medium, but did not inhibit Δaac S. cerevisiae in glucose-containing medium. It is hypothesized that ascosteroside D inhibits ATP production in mitochondria.

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关键词

Analytical chemistry,Screening,Life Sciences,general,Microbiology,Medicinal Chemistry,Organic Chemistry,Bacteriology,Bioorganic Chemistry

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