Bio-stimuli-responsive multi-scale hyaluronic acid nanoparticles for deepened tumor penetration and enhanced therapy.

Mengmeng Huo,Wenyan Li,Arka Sen Chaudhuri,Yuchao Fan,Xiu Han,Chen Yang,Zhenghong Wu,Xiaole Qi

Carbohydrate Polymers（2017）

引用 29|浏览3

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摘要

•Multi-scale HA nanoparticles encapsulated with PAMAM dendrimers were developed.•The fine bio-stimuli-responsive properties of HA/PAMAM nanoparticles was verified.•The in vitro tumor spheroids deeply penetration of HA/PAMAM-FITC was confirmed.•HA/PAMAM-FITC showed prolonged systematic circulation in mice bearing H22 tumor.•HA/PAMAM-MTX demonstrated higher antitumor activity in H22 sarcoma mice.

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关键词

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (PubChem CID: 2723939),Adipicdihydrazide (PubChem CID: 66117),Fluorescein isothiocyanate (PubChem CID: 18730),Methotrexate (PubChem CID: 126941),Sodium hyaluronate (PubChem CID: 3084049)

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