Transdermal delivery of propranolol hydrochloride through chitosan nanoparticles dispersed in mucoadhesive gel.

•Propranolol-HCL loaded chitosan nanoparticles have been prepared successfully using ionic gelation technique.•Various formulation parameters were found to affect the properties of the chitosan nanoparticles.•Nanoparticles dispersed into gels characterized by having thixotropic behaviour with sustained drug release properties.