A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase.

Liyun Zhang,Jun Cheng Er,Hao Jiang,Xin Li,Zhaofeng Luo,Thomas Ramezani,Yi Feng,Mui Kee Tang,Young-Tae Chang,Marc Vendrell

CHEMICAL COMMUNICATIONS（2016）

引用 19|浏览5

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摘要

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

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