Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome.

Sebastian Stentzel,Beate Hagl, Felicitas Abel,Barbara C Kahl,Anita Rack-Hoch,Barbara M Bröker,Ellen D Renner

CLINICAL INFECTIOUS DISEASES（2017）

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摘要

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

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关键词

S. aureus,STAT3,hyper-IgE Syndrome,HIES,Th17,cystic fibrosis,adaptive immunity,specific IgG

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