The effect of lamotrigine and phenytoin on bone turnover and bone strength: A prospective study in Wistar rats.

Julius Simko,Iva Karesova,Jan Kremlacek,Sona Fekete,Eva Zimcikova,Jana Malakova,Helena Zivna,Martin Valis,Vladimir Palicka

Epilepsy Research（2016）

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摘要

•Lamotrigine has no effect on the BMD, BTM or mechanical strength in gonadally intact animals.•Although a low dose of PHT was associated with enhanced BTM, it did not affect BMD or the biomechanical properties of the bones, similar to the results observed for LTG.•LTG has no effect on the BMD, BTM or mechanical strength in gonadally intact animals.•A low dose of PHT was associated with enhanced BTM.•The low dose of PHT did not affect BMD or the biomechanical properties of the bones.

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关键词

Bone mineral density,Bone turnover markers,Bone alkaline phosphatase,Amino-terminal propeptide of procollagen type I,Osteoprotegerin/receptor activator of nuclear factor kappa B ratio,Sclerostin

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