Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia.

Barbara Sjouke,Reyhana Yahya,Michael W T Tanck,Joep C Defesche,Jacqueline de Graaf,Albert Wiegman,John J P Kastelein,Monique T Mulder,G Kees Hovingh,Jeanine E Roeters van Lennep

Journal of Clinical Lipidology（2017）

引用 16|浏览25

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摘要

•Patients with autosomal dominant hypercholesterolemia (ADH) have high Lp(a) levels.•It is not completely known whether these levels are gene-dose-dependent.•We studied whether Lp(a) levels differ among bi-allelic ADH mutations carriers and their relatives.•Plasma Lp(a) levels were increased in bi-allelic ADH patients compared with both mono-allelic and unaffected relatives.

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关键词

Lipoprotein(a),Homozygous autosomal dominant hypercholesterolemia,Familial hypercholesterolemia

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