Behavioral assessment of neuropathic pain, fatigue, and anxiety in experimental autoimmune encephalomyelitis (EAE) and attenuation by interleukin-10 gene therapy.

Peter M Grace,Lisa C Loram,John P Christianson,Keith A Strand,Johanna G Flyer-Adams,Kathryn R Penzkover,John R Forsayeth,Anne-Marie van Dam,Melissa J Mahoney,Steven F Maier,Raymond A Chavez,Linda R Watkins

Brain, Behavior, and Immunity（2017）

引用 47|浏览12

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摘要

•Rat EAE was associated with neuropathic pain, anxiety and fatigue.•These symptoms were attenuated by a novel IL-10 gene therapy formulation.•Depressed wheel running preceded motor deficit, and may predict symptom onset.

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关键词

EAE,IL-10,IFA,MS,MOG

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