TGF-β signalling pathways in different compartments of the lower airways of stable COPD patients.

Antonino Di Stefano,Claudia Sangiorgi,Isabella Gnemmi,Paolo Casolari,Paola Brun,Fabio L M Ricciardolo,Marco Contoli,Alberto Papi,Pio Maniscalco,Paolo Ruggeri,Giuseppe Girbino,Francesco Cappello, Stelios Pavlides,Yike Guo,Kian Fan Chung,Peter J Barnes,Ian M Adcock,Bruno Balbi,Gaetano Caramori

Chest（2018）

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摘要

Expression of TGF-βs and their regulatory proteins is distinct within different lower airway compartments in stable COPD. Selective reduction in TGF-β1 and enhanced BAMBI expression may be associated with the increase in autoimmunity in COPD.

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关键词

airway inflammation,autoimmunity,BAMBI,CTGF,SMAD,TGF-β

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