Synthesis of [ 15 N]-cholamine bromide hydrobromide.

Judy Szeto, Remy Lemoine, Rosary Nguyen,Lori L Olson,Mary J Tanga

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS（2018）

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摘要

[N-15]-Cholamine is an isotope tag for metabolomics research, because it possesses 2 important properties: an NMR active isotope and a permanent charge for MS sensitivity. Here, we present a scalable synthesis of [N-15]-cholamine.

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关键词

[N-15]-cholamine bromide hydrobromide,carboxylic acid metabolites,chemo-selective tag,smart isotope tag

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