Molecular and functional characterization of two malic enzymes from Leishmania parasites.

Lucila Giordana, Máximo Hernán Sosa,Alejandro E Leroux,Elkin F Rodas Mendoza,Patricia Petray,Cristina Nowicki

Molecular and Biochemical Parasitology（2018）

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摘要

•The two isoforms of leishmanial malic enzyme exhibit an identity of about 55%.•Only one of the two isozymes is allosterically activated by l-aspartate.•Both malic enzyme isoforms specifically catalyze NADPH production.•The two isozymes appear to exhibit a species-specific expression pattern.

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关键词

Leishmania,Malic enzymes,NADPH production,Redox metabolism

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