The involvement of prostaglandin E 2 in interleukin-1β evoked anorexia is strain dependent.

Anna Nilsson,Louise Elander,Martin Hallbeck,Unn Örtegren Kugelberg,David Engblom,Anders Blomqvist

Brain, Behavior, and Immunity（2017）

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摘要

•The role of induced PGE2 in IL-1β evoked anorexia is strain dependent.•Mice on a DBA/1 background with deletion of mPGES-1 show attenuated anorexia.•C57BL/6 mice with deletion of mPGES-1 or EP receptors display normal anorexia.•In the most used mouse strain, C57BL/6, PGE2 is not mediating inflammatory induced anorexia.

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关键词

Anorexia,Prostaglandin E2,EP receptors,Interleukin-1,Cyclooxygenase-2,Mice

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