Population pharmacokinetics of piperacillin continuous infusion in critically ill patients.

Sofie A M Dhaese,Jason A Roberts,Mieke Carlier,Alain G Verstraete,Veronique Stove,Jan J De Waele

International Journal of Antimicrobial Agents（2018）

引用 43|浏览14

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摘要

•Piperacillin population pharmacokinetic models mainly rely on intermittent infusion (II) data.•II PK models may underestimate piperacillin continuous infusion (CI) clearance.•High-dose (24 g/24 h) piperacillin CI may not always ensure adequate exposure.

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关键词

Beta-lactam antibiotic,Pharmacokinetics,Piperacillin,Continuous infusion,Critically ill

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