Maternal undernutrition during early pregnancy inhibits postnatal growth of the tibia in the female offspring of rats by alteration of chondrogenesis.

Tomoko Kimura,Kodai Hino, Tadaaki Kono,Atsushi Takano,Norihisa Nitta,Noritoshi Ushio,Shinjiro Hino,Ryuta Takase, Motoi Kudo,Yataro Daigo,Wataru Morita,Mitsuyoshi Nakao,Masato Nakatsukasa,Toshihiro Tamagawa,Ashiq Mahmood Rafiq,Akihiro Matsumoto,Hiroki Otani,Jun Udagawa

General and Comparative Endocrinology（2018）

引用 11|浏览18

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摘要

•Malnutrition on early embryonic stage affects postnatal tibial growth in female rats.•Response to IGF1 on chondrocyte proliferation was attenuated by malnutrition.•Type II collagen production of chondrocytes was reduced by malnutrition.•Chondrocyte-related gene expression might be altered by transactivator gene Sp1.

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关键词

Undernutrition,Early embryonic period,Tibia,Chondrocyte,Postnatal growth

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