Bone marrow-derived mesenchymal stem cells induced by inflammatory cytokines produce angiogenetic factors and promote prostate cancer growth.

Ke-Qin Yang,Yan Liu,Qing-Hua Huang,Ning Mo,Qing-Yun Zhang,Qing-Gui Meng,Ji-Wen Cheng

BMC cancer（2017）

引用 37|浏览10

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摘要

MSCs stimulated by pro-inflammatory cytokines increase the expression of PDGF and VEGF via the NRF2-HIF-1α pathway and accelerate prostate cancer growth in mice.

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关键词

Prostate cancer,Mesenchymal stem cells,Angiogenesis,HIF-1α,NRF2,Inflammation,PDGF,VEGF

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