MiR-136 contributes to pre-eclampsia through its effects on apoptosis and angiogenesis of mesenchymal stem cells.

Liqin Ji,Liping Zhang,Yani Li,Li Guo, Ni Cao, Zhiying Bai, Yingchun Song, Zhao Xu,Juan Zhang,Chunhua Liu,Xiaoxing Ma

Placenta（2017）

引用 44|浏览7

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摘要

•MSCs derived from PE grew more slowly and manifest more apoptosis.•MiR-136 suppressed MSC proliferation and promoted apoptosis.•Supernatants from MSCs overexpressing miR-136 inhibits HUVEC capillary formation.•MiR-136 could affect MSC through suppressing the expression of BCL2 and VEGF.

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关键词

MiR-136,Mesenchymal stem cells,Preeclampsia,Apoptosis,Angiogenesis,BCL2

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