Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
Nature genetics, Volume 49, Issue 7, 2017, Pages 978-985.
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmissio...More
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