Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

    Daniel J Weiner
    Daniel J Weiner
    Emilie M Wigdor
    Emilie M Wigdor
    Aysu Okbay
    Aysu Okbay
    Jonas Bybjerg-Grauholm
    Jonas Bybjerg-Grauholm

    Nature genetics, Volume 49, Issue 7, 2017, Pages 978-985.

    Cited by: 50|Bibtex|Views9|Links
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    Abstract:

    Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmissio...More

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