Laser Peripheral Iridotomy versus Trabeculectomy as an Initial Treatment for Primary Angle-Closure Glaucoma.

Purpose. To compare laser peripheral iridotomy (LPI) with trabeculectomy as an initial treatment for primary angle-closure glaucoma (PACG) with peripheral anterior synechiae (PAS) >= 6 clock hours. Methods. Patients were drawn from two randomized controlled trials. 38 eyes of 38 patients (PAS >= 6 clock hours) were treated with LPI (group 1) while 111 eyes of 111 PACG patients (PAS >= 6 clock hours) underwent primary trabeculectomy (group 2). All patients underwent a comprehensive ophthalmic examination at baseline and at postoperative visits and were followed up for a minimum of one year. Results. Group 2 had higher baseline IOP (45.7 +/- 14.8mmHg versus 34.3 +/- 14.3 mmHg) than group 1 and more clock hours of PAS (10.4 +/- 1.9 versus 9.0 +/- 2.2). IOPs at all postoperative visits were significantly lower in group 2 than in group 1 (p = 0 000). Five eyes in group 1 required trabeculectomy. 17 of the 38 eyes in group 1 (44.7%) required IOP-lowering medications as compared to seven of the 111 eyes in group 2 (6.3%). Cataract progression was documented in 2 eyes (5.3%) in group 1 and 16 eyes (14.4%) in group 2. Conclusions. Primary trabeculectomy for PACG (PAS >= 6 clock hours) is more effective than LPI in lowering IOP.