Therapeutic progenitor cell application for tissue regeneration: Analyzing the impact of toll-like receptor signaling on c-kit + cell migration following ischemia-reperfusion injury in vivo.

•Artificially applied c-kit+ cells interact with the target organ endothelium following ischemia-reperfusion injury.•Therapeutic blockade of TLR signaling for anti-inflammatory purposes might interfere with regenerative cell-based therapy protocols.•Firm c-kit+ cell interaktion with target organ endothelium following ischemia-reperfusion depends on TLR-signalling.