Mobilization of Hematopoietic Progenitor Cells with Standard or Reduced Dose Filgrastim after Vinorelbine in Multiple Myeloma Patients. a Randomized Prospective Single Center Phase II Study.

Panagiotis Samaras,Markus F Rütti,Burkhardt Seifert,Helga Bachmann,Urs Schanz, Maya Eisenring,Christoph Renner,Antonia Maria Susanne Müller,Adrian Schmidt,Axel Mischo,Ivo Fuchs,Mario Bargetzi,Markus G Manz,Roger Stupp,Ulf Petrausch,Frank Stenner-Liewen

Biology of Blood and Marrow Transplantation（2018）

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摘要

•The use of vinorelbine with reduced-dose filgrastim resulted in high hematopoietic progenitor cell collection rates.•Leukapheresis sessions could be started at the anticipated collection date with high predictability.•Patients receiving less filgrastim reported lower bone pain intensity.•Treatment cost were lower in the study arm with reduced dose filgrastim.

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关键词

Hematopoietic progenitor cell mobilization,Chemomobilization,Vinorelbine,Filgrastim,Multiple myeloma,Autologous stem cell transplantation

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