Monocyte chemotactic protein-induced protein 1 controls allergic airway inflammation by suppressing IL-5-producing T H 2 cells through the Notch/Gata3 pathway.

Hui Peng,Huan Ning,Qinghong Wang,Wenbao Lu,Yingzi Chang,Tony T Wang,Jinping Lai,Pappachan E Kolattukudy,Rong Hou,Daniel F Hoft,Mark S Dykewicz,Jianguo Liu

Journal of Allergy and Clinical Immunology（2018）

引用 25|浏览17

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摘要

Our study reveals that MCPIP1 regulates the development and function of IL-5-producing T2 cells through the Notch/Gata3 pathway. MCPIP1 represents a new and promising target for the treatment of asthma and other T2-mediated diseases.

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关键词

RNA-Binding protein,MCPIP1,mRNA decay,TH2 cells,IL-4,IL-5,IL-13,Gata3,Notch,asthma

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