Costing analysis and anthropological assessment of the vaccine supply chain system redesign in the Comé District (Benin).

•Incremental financial costs for new system implementation amounted to US 55,148$.•Economic cost per dose administered increased from US$0.09 to US$ 0.15.•Health workers’ motivation and professional awareness were improved.•Transport cost at health facility level is considerably reduced.•Integrating other health commodities could increase efficiency of the underused redesigned system.