Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

Rob C Oslund,Xiaoyang Su,Michael Haugbro,Jung-Min Kee,Mark Esposito,Yael David,Boyuan Wang,Eva Ge,David H Perlman,Yibin Kang,Tom W Muir,Joshua D Rabinowitz

NATURE CHEMICAL BIOLOGY（2017）

引用 38|浏览31

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摘要

Bisphosphoglycerate mutase (BPGM) drives phosphoglycerate mutase 1 (PGAM1) phosphorylation, which is required for glycolytic flux. Loss of BPGM is partially compensated by 1,3-BPG directly phosphorylating PGAM1, sustaining glycolytic flux but diverting metabolites for serine synthesis.

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关键词

serine pathway flux

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