Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin.

Corina Buta,Eva Benabou,Marie Lequoy,Hélène Régnault,Dominique Wendum, Fatiha Meratbene,Hamza Chettouh,Lynda Aoudjehane,Filomena Conti,Yves Chrétien,Olivier Scatton,Olivier Rosmorduc,Françoise Praz,Laetitia Fartoux,Christèle Desbois-Mouthon

Journal of experimental & clinical cancer research : CR（2016）

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摘要

Autocrine heregulin-1ß loop is uncommon in HCC and HER3 mRNA expression is differentially influenced by hepatitis viruses. Insulin is a negative regulator of HER3 protein expression and function in HCC cells. Altogether these data may explain why HER3 and heregulin-1ß expression have no prognostic value and suggest that HCC patients are unlikely to derive benefit from HER3-targeted monotherapies.

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关键词

HER3/ERBB3,Hepatitis virus,Insulin receptor,Liver cancer

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