Thymosin β10 as a predictive biomarker of response to 5-fluorouracil chemotherapy in cholangiocarcinoma.

Sirinapa Sribenja,Nichapavee Natthasirikul,Kulthida Vaeteewoottacharn,Kanlayanee Sawanyawisuth,Chaisiri Wongkham,Patcharee Jearanaikoon,Sopit Wongkham

Annals of hepatology（2016）

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摘要

The present novel findingsof T?10 connected with drug resistance as shown in this study provides a new insight for the therapeutic value of T?10 as a predictive biomarker of 5-FU chemoresistance. Inhibiting T?10 may be a valuable adjunct for suppression of ABC transporters and sensitizing chemotherapy treatment, especially 5-FU in CCA patients.

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