Site-specific incorporation of phosphotyrosine using an expanded genetic code

Christian Hoppmann,Allison Wong,Bing Yang,Shuwei Li,Tony Hunter,Kevan M Shokat,Lei Wang

NATURE CHEMICAL BIOLOGY（2017）

引用 84|浏览9

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摘要

genetically encoded unnatural amino acid analog and its acidic deprotection enable the site-specific incorporation of phosphotyrosine (pTyr) into proteins such as ubiquitin, where it can be used to study the function of this phosphorylated residue.

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关键词

Chemical modification,Chemical tools,Post-translational modifications,Proteins,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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