Comparison of Ca puffs evoked by extracellular agonists and photoreleased IP.

Cell Calcium（2017）

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摘要

•GPCR agonists and photoreleased i-IP3 evoke Ca2+ puffs at overlapping sites.•Puffs evoked by GPCR agonists and photoreleased i-IP3 have similar kinetics and spatial spread.•Photoreleased i-IP3 faithfully mimics puffs evoked by the physiological IP3 pathway.•Muscarinic and bradykinin receptors access the same IP3 receptors.

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关键词

Ca2+ puffs,IP3,GPCRs,Calcium imaging,Signaling nanodomains

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