Human asthma is characterized by more IRF5+ M1 and CD206+ M2 macrophages and less IL-10+ M2-like macrophages around airways compared with healthy airways.

Christina Draijer,Carian E Boorsma,Patricia Robbe,Wim Timens,Machteld N Hylkema,Nick H Ten Hacken,Maarten van den Berge,Dirkje S Postma,Barbro N Melgert

The Journal of allergy and clinical immunology（2016）

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摘要

In asthma, macrophage polarization is altered from a state associated with anti-inflammatory responses to a state associated with inflammation as compared to control. Macrophage polarization states is linked to disease severity, sex and ICS treatment.

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