DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, pp. 889-905, 2017.

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Keywords:
DJ-1/PARK7reactive oxygen speciessepsisbacterial clearanceNADPH oxidase

Abstract:

Rationale: Effective and rapid bacterial clearance is a fundamental determinant of outcomes in sepsis. DJ-1 is a well-established reactive oxygen species (ROS) scavenger. Objectives: Because cellular ROS status is pivotal to inflammation and bacterial killing, we determined the role of DJ-1 in bacterial sepsis. Methods: We used cell and m...More

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