Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model.

Peter Pushko,Xiangjie Sun,Irina Tretyakova,Rachmat Hidajat,Joanna A Pulit-Penaloza,Jessica A Belser,Taronna R Maines,Terrence M Tumpey

Vaccine（2016）

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摘要

•H10 VLPs and Quadri-subtype H5/H7/H9/H10 VLPs were evaluated in a ferret H10 challenge model.•Immunogenicity of VLPs was confirmed including serum HI antibody reactions with divergent HA subtypes.•Both mono-subtype and quadri-subtype VLPs induced protection against heterologous H10N1 virus challenge.

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关键词

Influenza,Virus-like particles,VLP,H10N8,Recombinant vaccine,Baculovirus

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